Sevilla was originally an Iberian town. Under the Romans it flourished from the 2nd century BCE onward as Hispalis, and it was an administrative centre of the province of Baetica. The Silingi Vandals made it the seat of their kingdom early in the 5th century CE, but in 461 it passed under Visigothic rule. In 711 the town fell to the Muslims, and under their rule Ixvillia, as it was then called, flourished. It became a leading cultural and commercial centre under the ʿAbbādid dynasty and the subsequent Almoravid and Almohad confederations.

As the Almohad capital in the 12th century, Sevilla enjoyed great prosperity and ambitious building programs. But after the Muslim possession of Sevilla was ended in 1248 by Spanish Christians under Ferdinand III, the substantial Moorish and Jewish minorities were driven into exile, and the local economy temporarily fell into ruin.

The Spanish discovery of the Americas brought new prosperity to the city. Sevilla became the centre of the exploration and exploitation of America through the Casa de Contratación (“House of Trade”), which was established there in 1503 to regulate commerce between Spain and the New World. For two centuries Sevilla was to hold a dominant position in Spain’s New World commerce; it was the site of the chief mint for gold and silver from the Americas, and many Spanish emigrants to the New World sailed from its quays. Sevilla was in fact the richest and most populous city in Spain in the 16th century, with some 150,000 inhabitants in 1588.

This brilliance was fleeting, however, since Sevilla’s prosperity was based almost entirely on the exploitation of the colonies rather than on local industry and trade. As a result, Sevilla’s economy declined in the 17th century, though its cultural life underwent a great flowering at that time. The painters Diego Velázquez, Francisco de Zurbarán, and Bartolomé Esteban Murillo, the sculptor Juan Martínez Montañés, and the poet Fernando de Herrera are the glories of Sevilla and of Spain. Miguel de Cervantes conceived of his novel Don Quixote while he was confined in Sevilla’s jail.